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KMID : 0811720120160020097
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Korean Journal of Physiology & Pharmacology
2012 Volume.16 No. 2 p.97 ~ p.106
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Standard Error of Empirical Bayes Estimate in NONMEM? VI
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Kang Dong-woo
Bae Kyun-Seop
Brett E. Houk
Radojka M. Savic
Mats O. Karlsson
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Abstract
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The pharmacokinetics/pharmacodynamics analysis software NONMEM? output provides model parameter estimates and associated standard errors. However, the standard error of empirical Bayes estimates of inter-subject variability is not available. A simple and direct method for estimating standard error of the empirical Bayes estimates of inter-subject variability using the NONMEM? VI internal matrix POSTV is developed and applied to several pharmacokinetic models using intensively or sparsely sampled data for demonstration and to evaluate performance. The computed standard error is in general similar to the results from other post-processing methods and the degree of difference, if any, depends on the employed estimation options.
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KEYWORD
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NONMEM, Standard error of empirical bayes estimate, Nonlinear mixed effects modeling
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